Yes, you can.
Let's write some context:
jQuery('#myGrid');
{name:'Name', index:'name', sortable:true, align:'left', required: true, editable:true, edittype:'text'}
And now, when you click on some button, you call a function that should disable sorting from the Name column. This is how the function should look.
function disableSorting(){
jQuery('#myGrid').setColProp('Name', {sortable: false});
}
Tested and working :)
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