I think this is very doable ... I would start with Electron - this is an environment for creating your own applications with web technologies such as JavaScript, HTML and CSS. It takes care of the hard parts so you can focus on the core of your application. Nowadays, it also looks like a "standard." All this uses it as desktop applications:
- Slack
- Atom (GitHub editor)
- Wordpress app
- Visual Studio Code (the powerful editor I use these days)
- WhatsApp (their desktop application uses React and wrap with Electorn).
Last but not least, take a look at: http://www.youtube.com/watch?v=j8oFAr1YR-0
It contains all the information you need to launch and create your application.
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