The first thing to remember is that WF is not a BPM tool, but rather a framework that can be used to create a reliable and flexible set of business flows. If you are looking for a solution that provides you with many built-in functions in which you do not need to do any encodings, but simply overlay shapes on a sheet - WF is not your tool.
However, I would recommend WF highly. Firstly, the performance in WF 4.0 is very good. Secondly, it is distributed through a web server farm. Third, this flexibility gives you the strength you need along the way to get to those extreme cases.
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