This issue seems to be resolved in the latest version of EPPlus (4.0.x)
EDIT: Add link links to pages that indicate improved memory management in EPPlus 4.0.4.
https://epplus.codeplex.com/releases/view/118053#ReviewsAnchor
User reviews about memory performance improvements in version 4.x in comparison with the 3.x version .
https://epplus.codeplex.com/wikipage?title=Roadmap
Version 4.0: a new cell to improve insertion, removal of performance and memory consumption
This link explains how to optimize the loading of a large number of cells.
http://epplus.codeplex.com/wikipage?title=FAQ&referringTitle=Documentation
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