Creating a new ASP.NET application - finding a good structure

I am starting to build a new large-scale ASP.NET website that should support a lot of traffic, Ajax. clean page design (not too heavy, but quite functional), web services, databases, clouds and more. Being a little “outdated” with the progress made in the ASP.NET arena (working on another non-web .NET project), I was wondering what today is the “best practice” used to create a [very] big new site.

Is MVC 3 the most acceptable? are they better, easier to develop, more popular framework?

Any help would be greatly appreciated.

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ASP.NET MVC, , , / , .

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, , , , MVC3 . , , , JQuery UI (MVC3 JQuery , . WebForms, MVC , MVC.

WCF -.

LINQ to Entities , , . , SQL Azure.

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